Health & Fitness:

Disease

HIV symptoms

 

The human immunodeficiency virus (HIV) is a retrovirus that infects T cells and attacks the immune system, resulting in reduced T cell numbers, immune deficiency, and opportunistic infections - the syndrome known as acquired immune deficiency syndrome (AIDS).

The symptoms of infection vary with both the individual and time. Generally, at the time of exposure and initial infection, the person will experience flu-like symptoms, the signs associated with an immune response against the viral invader. The virus then hides inside the immune cells for a varying period of time. When the viral load increases to a certain point, the T cell count drops, hindering the immune response to other pathogens. HIV infection is mostly asymptomatic until the onset of immunodeficiency when infections that usually do not affect healthy adults begin to appear, with symptoms indicative of the particular disorder. HIV-infected individuals also tend to exhibit weight loss, digestive problems, and swollen lymph nodes.

Image: Kaposi's sarcoma, a vascular tumor seen in AIDS patients

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HIV Signs and Symptoms by Phase of Infection

Physical symptoms

Acute (early) phase: fever, swollen lymph nodes, rash, fatigue, headache

Latent (middle) phase: asymptomatic, can last a decade or more

Early symptomatic (late) stage: weight loss, diarrhea, headache, fever, swollen lymph nodes, sore throat and muscles, skin disorders

Final stage - AIDS: opportunistic infections (e.g., pneumocystis carnii pneumonia, thrush, candidiasis and cryptococcus fungal infection, kaposi's sarcoma (vascular tumor), tuberculosis, toxoplasmosis, simultaneous herpes simplex infection)

Clinical signs

Latent phase: Presence of HIV antibody, decreasing CD4 T cell count, RNA test indicating presence of the virus.

AIDS: CD4 count <200 and presence of opportunist infections or positive HIV antibody/RNA test

Quick Facts

  • HIV infection does not have definitive physical symptoms until late in the disease, though blood tests can monitor T cell levels and viral load (the amount of virus in the blood).
  • Late stage infection results in acquired immune deficiency characterized by a syndrome of opportunistic infections.
  • HIV infection is diagnosed by regular blood tests in high risk populations because it can be transmitted in the absence of symptoms.
  • Antiviral medications can be used to prevent symptom and AIDS onset once a diagnosis of HIV infection has been made.
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Did I Just Contract HIV? Symptoms of HIV Infection

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